| Data | Mandante | Visitante |
Vitória do Mandante |
Empate |
Vitória do Visitante |
|
| 11/05/2021 | Montevidéo City Torque | 1x1 | Independiente | 31.3 % | 24.1 % | 44.6 % |
| 11/05/2021 | Metropolitanos | 0x1 | Athletico Paranaense | 32.0 % | 23.9 % | 44.1 % |
| 11/05/2021 | Talleres | 0x0 | Tolima | 56.0 % | 28.8 % | 15.2 % |
| 11/05/2021 | Red Bull Bragantino | 2x0 | Emelec | 9.1 % | 17.9 % | 73.0 % |
| 12/05/2021 | 12 de Octubre | 1x2 | Huachipato | 31.4 % | 54.1 % | 14.5 % |
| 12/05/2021 | San Lorenzo | 1x2 | Rosario Central | 17.8 % | 25.7 % | 56.5 % |
| 12/05/2021 | Ceará | 0x0 | Arsenal (Arg) | 47.4 % | 43.2 % | 9.4 % |
| 12/05/2021 | Bolívar | 2x2 | Jorge Wilstermann | 53.5 % | 22.9 % | 23.6 % |
| 12/05/2021 | Atlético Goianiense | 0x0 | Palestino | 66.3 % | 27.1 % | 6.6 % |
| 13/05/2021 | Guabirá | 0x1 | Bahia | 2.1 % | 5.2 % | 92.7 % |
| 13/05/2021 | Aucas | 2x1 | FBC Melgar | 11.2 % | 18.6 % | 70.2 % |
| 13/05/2021 | River Plate (Par) | 2x1 | Sport Huancayo | 76.0 % | 17.0 % | 6.9 % |
| 13/05/2021 | Peñarol | 4x0 | Corinthians | 68.6 % | 19.8 % | 11.7 % |
| 13/05/2021 | Libertad | 1x0 | Newell's Old Boys | 65.1 % | 20.5 % | 14.4 % |
| 13/05/2021 | Aragua | 1x2 | La Equidad | 9.9 % | 14.7 % | 75.3 % |
| 13/05/2021 | Grêmio | 3x1 | Lanús | 73.4 % | 18.6 % | 8.0 % |
| 18/05/2021 | Independiente | 1x0 | Bahia | 51.7 % | 23.3 % | 24.9 % |
| 18/05/2021 | River Plate (Par) | 2x1 | Peñarol | 5.7 % | 13.3 % | 81.0 % |
| 18/05/2021 | Talleres | 0x1 | Red Bull Bragantino | 50.7 % | 32.7 % | 16.6 % |
| 19/05/2021 | Emelec | 2x0 | Tolima | 66.5 % | 21.8 % | 11.8 % |
| 19/05/2021 | Rosario Central | 5x0 | Huachipato | 44.4 % | 31.9 % | 23.7 % |
| 19/05/2021 | Jorge Wilstermann | 1x2 | Arsenal (Arg) | 20.3 % | 26.5 % | 53.1 % |
| 19/05/2021 | Athletico Paranaense | 1x0 | FBC Melgar | 43.2 % | 36.5 % | 20.3 % |
| 19/05/2021 | Aucas | 3x0 | Metropolitanos | 47.1 % | 21.1 % | 31.7 % |
| 19/05/2021 | Atlético Goianiense | 0x0 | Libertad | 36.2 % | 30.5 % | 33.3 % |
| 20/05/2021 | 12 de Octubre | 0x2 | San Lorenzo | 57.1 % | 34.3 % | 8.6 % |
| 20/05/2021 | Guabirá | 0x4 | Montevidéo City Torque | 6.6 % | 11.6 % | 81.8 % |
| 20/05/2021 | Ceará | 2x0 | Bolívar | 75.3 % | 24.5 % | 0.2 % |
| 20/05/2021 | Corinthians | 5x0 | Sport Huancayo | 82.1 % | 13.8 % | 4.1 % |
| 20/05/2021 | Newell's Old Boys | 3x1 | Palestino | 65.6 % | 32.9 % | 1.4 % |
| 20/05/2021 | Lanús | 4x1 | La Equidad | 71.2 % | 23.3 % | 5.5 % |
| 20/05/2021 | Aragua | 2x6 | Grêmio | 1.2 % | 3.9 % | 94.9 % |
| 25/05/2021 | Newell's Old Boys | 1x1 | Atlético Goianiense | 30.9 % | 57.1 % | 12.1 % |
| 25/05/2021 | Palestino | 1x2 | Libertad | 14.4 % | 22.3 % | 63.2 % |
| 25/05/2021 | Emelec | 1x4 | Talleres | 74.2 % | 22.8 % | 3.0 % |
| 25/05/2021 | Tolima | 1x2 | Red Bull Bragantino | 36.3 % | 30.6 % | 33.1 % |
| 26/05/2021 | Rosario Central | 0x0 | 12 de Octubre | 81.6 % | 15.0 % | 3.4 % |
| 26/05/2021 | Huachipato | 0x3 | San Lorenzo | 44.9 % | 28.7 % | 26.4 % |
| 26/05/2021 | Independiente | 1x0 | Guabirá | 95.5 % | 3.7 % | 0.7 % |
| 26/05/2021 | Bahia | 2x4 | Montevidéo City Torque | 48.1 % | 26.6 % | 25.4 % |
| 26/05/2021 | Corinthians | 4x0 | River Plate (Par) | 52.6 % | 37.8 % | 9.6 % |
| 26/05/2021 | Sport Huancayo | 0x0 | Peñarol | 5.6 % | 8.0 % | 86.3 % |
| 27/05/2021 | Jorge Wilstermann | 1x0 | Ceará | 10.4 % | 32.7 % | 56.8 % |
| 27/05/2021 | Arsenal (Arg) | 3x1 | Bolívar | 73.7 % | 18.0 % | 8.2 % |
| 27/05/2021 | Athletico Paranaense | 4x0 | Aucas | 65.1 % | 30.3 % | 4.7 % |
| 27/05/2021 | FBC Melgar | 0x0 | Metropolitanos | 74.7 % | 15.0 % | 10.3 % |
| 27/05/2021 | Lanús | 0x0 | Aragua | 95.3 % | 3.6 % | 1.1 % |
| 27/05/2021 | La Equidad | 0x0 | Grêmio | 3.9 % | 13.1 % | 82.9 % |
| 13/07/2021 | América de Cáli | 0x1 | Athletico Paranaense | 49.5 % | 31.0 % | 19.5 % |
| 13/07/2021 | LDU Quito | 0x1 | Grêmio | 33.8 % | 20.5 % | 45.7 % |
| 14/07/2021 | Independiente del Valle | 0x2 | Red Bull Bragantino | 30.1 % | 28.6 % | 41.3 % |
| 14/07/2021 | Júnior Barranquilla | 3x4 | Libertad | 58.1 % | 23.6 % | 18.3 % |
| 14/07/2021 | Sporting Cristal | 2x1 | Arsenal (Arg) | 8.3 % | 19.4 % | 72.3 % |
| 15/07/2021 | Nacional (Uru) | 1x2 | Peñarol | 35.0 % | 23.9 % | 41.1 % |
| 15/07/2021 | Santos | 1x0 | Independiente | 79.8 % | 17.0 % | 3.1 % |
| 15/07/2021 | Táchira | 2x2 | Rosario Central | 41.9 % | 17.9 % | 40.2 % |
| 20/07/2021 | Athletico Paranaense | 4x1 | América de Cáli | 63.8 % | 27.2 % | 8.9 % |
| 20/07/2021 | Grêmio | 1x2 | LDU Quito | 64.2 % | 18.6 % | 17.2 % |
| 21/07/2021 | Red Bull Bragantino | 1x1 | Independiente del Valle | 87.9 % | 10.8 % | 1.3 % |
| 21/07/2021 | Libertad | 0x1 | Júnior Barranquilla | 48.3 % | 21.9 % | 29.8 % |
| 21/07/2021 | Arsenal (Arg) | 1x1 | Sporting Cristal | 66.8 % | 20.9 % | 12.2 % |
| 22/07/2021 | Peñarol | 0x1 | Nacional (Uru) | 49.0 % | 23.2 % | 27.8 % |
| 22/07/2021 | Independiente | 1x1 | Santos | 17.1 % | 29.0 % | 53.9 % |
| 22/07/2021 | Rosario Central | 1x0 | Táchira | 55.5 % | 17.4 % | 27.1 % |
| 10/08/2021 | Rosario Central | 3x4 | Red Bull Bragantino | 4.8 % | 29.3 % | 65.9 % |
| 11/08/2021 | Sporting Cristal | 1x3 | Peñarol | 20.6 % | 21.6 % | 57.8 % |
| 12/08/2021 | Santos | 2x1 | Libertad | 60.5 % | 21.2 % | 18.4 % |
| 12/08/2021 | LDU Quito | 1x0 | Athletico Paranaense | 49.9 % | 26.5 % | 23.6 % |
| 17/08/2021 | Red Bull Bragantino | 1x0 | Rosario Central | 80.7 % | 13.7 % | 5.6 % |
| 18/08/2021 | Peñarol | 1x0 | Sporting Cristal | 76.8 % | 15.2 % | 7.9 % |
| 19/08/2021 | Libertad | 1x0 | Santos | 34.1 % | 24.2 % | 41.7 % |
| 19/08/2021 | Athletico Paranaense | 4x2 | LDU Quito | 38.8 % | 29.8 % | 31.4 % |
| 23/09/2021 | Peñarol | 1x2 | Athletico Paranaense | 35.7 % | 28.5 % | 35.8 % |
| 22/09/2021 | Red Bull Bragantino | 2x0 | Libertad | 65.6 % | 19.5 % | 14.9 % |
| 29/09/2021 | Libertad | 1x3 | Red Bull Bragantino | 23.1 % | 23.5 % | 53.4 % |
| 30/09/2021 | Athletico Paranaense | 2x0 | Peñarol | 64.5 % | 22.6 % | 12.9 % |
| 20/11/2021 | Red Bull Bragantino | 0x1 | Athletico Paranaense | 53.8 % | 26.7 % | 19.5 % |